| Pair Name | Daidzein, Topotecan | ||
| Phytochemical Name | Daidzein (PubChem CID: 5281708 ) | ||
| Anticancer drug Name | Topotecan (PubChem CID: 60700 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Daidzein, Topotecan | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Down-regulation | Expression | ABCG2 | hsa9429 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| In Vivo Model | Adult female athymic nude mice (six-week-old) were injected with MCF7 cells (5×10⁶ cells/mouse) to construct subcutaneous breast cancer xenografts. | |||
| Result | Daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer. Pharmacol Res. 2019 Sep;147:104387. doi: 10.1016/j.phrs.2019.104387. | Click |
